CLINICAL PREDICTORS OF VENTRICULAR TACHYCARDIA INDUCED CARDIOMYOPATHY
CCC ePoster Library. Azizi Z. 10/26/19; 280518; 283
Dr. Zahra Azizi
Dr. Zahra Azizi
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Abstract
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BACKGROUND: Frequent Idiopathic Ventricular tachyarrhythmias (IVT) can lead to reversible ventricular dysfunction known as Tachycardia Induced Cardiomyopathy (TIC). Predicting factors that are associated with TIC are controversial. Therefore, we performed this study to determine incidence and predictors of TIC compared to patients with preserved ejection fraction (EF) who underwent catheter ablation.

METHODS AND RESULTS: Overall, 204 patients with IVT, who underwent ablation (VTA) between 2011-2017 at a single tertiary care center were studied. After excluding all patients with structural heart diseases, history of syncope and implanted device, 130 patients were analyzed. Univariate, multivariate logistic regression, and ROC curve were used to determine the likelihood of TIC compared to patients with preserved LVEF (EF>50%). Overall, 23 (17.6%) patients had EF under 50% of whom, 15 patients with more than 15% improvement in EF were considered as TIC (13(86.7%) male, with mean age of 59.50±19.04 years). Total of 103 patients with preserved EF more than 50% were considered as control. Mean Premature ventricular contraction (PVC)burden per day (30751.27± 16512.3 vs 16229.2± 15386.7, p=0.005) and PVC percentage (31.85±16.77 vs 15.01±13.19, p < 0.001) before VTA was higher in patients with TIC than patients with preserved LVEF. ROC Curve Analysis showed PVC burden of 19x103 per day and PVC percentage of 18.6% as the ideal cutoff point to differentiate TIC from patients with normal LVEF (Figure1). Multivariate logistic regression model showed higher PVC burden before VTA more than 19x103 per/day (OR=11.5, P=0.03) and PVC percentage more than 18.6% (OR=11.8, p=0.02) as the most significant predictor of TIC when adjusted for age, sex, history of hypertension, hyperlipidemia, diabetes mellitus and obstructive sleep apnea.

CONCLUSION: PVC burden greater than 19x103 per day and PVC percentage greater than 18.6% are the most significant risk factors for tachycardia induced cardiomyopathy.
BACKGROUND: Frequent Idiopathic Ventricular tachyarrhythmias (IVT) can lead to reversible ventricular dysfunction known as Tachycardia Induced Cardiomyopathy (TIC). Predicting factors that are associated with TIC are controversial. Therefore, we performed this study to determine incidence and predictors of TIC compared to patients with preserved ejection fraction (EF) who underwent catheter ablation.

METHODS AND RESULTS: Overall, 204 patients with IVT, who underwent ablation (VTA) between 2011-2017 at a single tertiary care center were studied. After excluding all patients with structural heart diseases, history of syncope and implanted device, 130 patients were analyzed. Univariate, multivariate logistic regression, and ROC curve were used to determine the likelihood of TIC compared to patients with preserved LVEF (EF>50%). Overall, 23 (17.6%) patients had EF under 50% of whom, 15 patients with more than 15% improvement in EF were considered as TIC (13(86.7%) male, with mean age of 59.50±19.04 years). Total of 103 patients with preserved EF more than 50% were considered as control. Mean Premature ventricular contraction (PVC)burden per day (30751.27± 16512.3 vs 16229.2± 15386.7, p=0.005) and PVC percentage (31.85±16.77 vs 15.01±13.19, p < 0.001) before VTA was higher in patients with TIC than patients with preserved LVEF. ROC Curve Analysis showed PVC burden of 19x103 per day and PVC percentage of 18.6% as the ideal cutoff point to differentiate TIC from patients with normal LVEF (Figure1). Multivariate logistic regression model showed higher PVC burden before VTA more than 19x103 per/day (OR=11.5, P=0.03) and PVC percentage more than 18.6% (OR=11.8, p=0.02) as the most significant predictor of TIC when adjusted for age, sex, history of hypertension, hyperlipidemia, diabetes mellitus and obstructive sleep apnea.

CONCLUSION: PVC burden greater than 19x103 per day and PVC percentage greater than 18.6% are the most significant risk factors for tachycardia induced cardiomyopathy.
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